Nexavar Tablets are consumed for treatment of renal cell carcinoma and hepatocellular carcinoma. They work by inhibiting activity of tyrosine protein kinases resulting in suppression of tumor growth. These tablets are formulated using sorafenib as main chemical compound having formula C21H16ClF3N4O3 and molecular weight of 464.825 g/mol. metabolism of Nexavar Tablets takes place by hepatic oxidation and glucuronidation with help of CYP3A4 & UGT1A9. They are known to have elimination half life of 25 to 48 hours with excretion mainly in feces.
Excellent protein binding of 99.5%
Have bioavailability range of 38 to 49%
Belongs to kinase inhibitor drug class